Scientists Discover Enzyme Capable of Treating Multiple Health Conditions
A team of scientists from medical research facilities in the United States and Brazil is investigating the potential benefits of the soluble guanylate cyclase (sGC) enzyme. Studies show this enzyme, normally found in the body, is limited, or even absent in people with many chronic health conditions.
Researchers believe using sGC as a therapeutic target could help increase the levels in patients with low or no concentration of the enzyme. By blocking histone deacetylase, an enzyme that aids tumor cells in dividing and growing, the expression of sGC could increase.
The results of the clinical trial using human breast cancer cells, published in The FASEB Journal, show that once researchers blocked histone deacetylase, the sGC levels in the cells increased, causing an increased production of cyclic GMP. (Cyclic GMP is a cyclic nucleoside that helps activate protein enzymes and is a potential mechanism for decreasing cancer cell growth.)
In addition to inhibiting cancer cell growth, increasing sGC levels helps relax smooth muscle cells. This relaxation can help diseases with muscular symptoms such as erectile dysfunction, overactive bladder, cardiovascular diseases, and pulmonary hypertension.
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