Genetic Alterations Predict Prostate Cancer Side Effect Risk

Posted on May 16, 2016 by Disability Help Group

Taxane drugs are a popular prostate cancer treatment, but these drugs come with serious side effects, such as peripheral neuropathy. Doctors at the Moffitt Cancer Center recently conducted a study to determine what causes some, but not all, patients to experience peripheral neuropathy.

Over 600 men with castrate-resistant metastatic prostate cancer who received docetaxel (a taxane drug) took part in the study, published in the Clinical Cancer Research journal.

Fifty of the participants, about eight percent, experienced severe peripheral neuropathy (painful, debilitating nerve damage), during the trials. After identifying the men who developed peripheral neuropathy, the researchers examined their DNA to look for genetic anomalies, called single nucleotide polymorphisms (SNPs).

Researchers found that the men who developed peripheral neuropathy had an SNP in their VAC14 gene. Identifying this gene may help doctors better assess the risks of docetaxel in individual patients. The new genetic research may also lead to the development of new drug options to treat prostate cancer.

If You Have Prostate Cancer and Can No Longer Work You May Qualify For Disability Benefits

Prostate cancer is a leading cause of death of men across all races, although it more commonly affects men over 65. It can be extremely debilitating, as it often has no early symptoms, which can make treatment much more difficult and time-consuming.

If cancer or cancer treatment has made it impossible for you to work and earn an income, you may qualify for Social Security disability benefits.

Filing a claim or appealing a disability claim denial can be a complicated, frustrating process. Do not do it alone. Disability Help Group provides assistance to disabled individuals; contact us at 800-800-2009 to schedule a consultation with one of our disability advocates today.