Targeted Immunotherapy Cures Autoimmune Enteritis Caused by Genetic Mutation
Researchers at the University of Basel and University Hospital Basel in Switzerland recently developed a cure for a patient with a rare genetic mutation that causes autoimmune enteritis.
The researchers found that a mutation in the CTLA-4 protein caused this patient to suffer from the autoimmune disease. Fortunately, as quickly as the researchers discovered the cause of the disease, they also found a cure.
Using targeted immunotherapy, the researchers administered a new type of monoclonal antibody group that prevented the patient’s T-cells from penetrating the mucous inside the intestine.
The drug blocked the adhesion molecule that allows T-cells to bind to immune cells and penetrate intestinal tissue blood vessels.
While the CTLA-4 mutation, which reduces the gene’s function, caused autoimmune enteritis in this instance, further research shows inhibition of this gene could help treat skin cancer.
Ipilimumab, a melanoma treatment drug, works similarly to the CTLA-4 mutation by inhibiting the gene. However, because this inhibition causes autoimmune intestinal inflammation, researchers are now looking to the discovery of this new mutation to help correlate ways to prevent that side effect of the treatment.
The researchers published their findings in the Journal of Allergy and Clinical Immunology.
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