Markers in Bladder Tumors Could Predict Lethality of Bladder Cancer and Improve Treatment
Researchers at the Ludwig Center at the University of Chicago have identified markers in bladder cancer tumors that could help in predicting the course and treatment of the disease. Three markers, in particular, stood out as causes of increased risk of death:
- The presence of poorly differentiated basal cells in the tumors of early stage bladder cancers.
- Overexpression of the cell division cycle 25C gene in those basal cells.
- The growth of new tumor tissue when researchers transplanted fragments of the tumor into mice.
The researchers used 71 bladder tumor tissue samples from cancer patients treated at their University. Using flow cytometry (i.e., analyzation of blood or bone marrow cells), they isolated specific subtypes of cells in the tumors and counted the number of certain cells in each sample.
This analysis, published in Scientific Reports, linked an excess of the basal tumor cell subtype with a three-fold increase in the risk of death.
When testing for cell division cycle 25C (CDC25C), researchers found the protein increased the patient’s risk of death even after removing the cancerous bladder. However, the increased risk of death disappeared when patients had previously undergone chemotherapy.
By investigating this protein’s presence, doctors could more accurately predict the benefits of chemotherapy treatment.
The tumor implantation test helped researchers determine the aggressiveness of tumors and their impact on the lethality of cancer. However, the researchers found that more invasive tumors were harder to predict. These tumors (from more advanced stage cancers) that grew when implanted in mice caused an estimated six-fold increase in the risk of death.
Bladder Cancer is the Fourth Most Common Cause of Cancer-Related Death for American Men
Bladder cancer can be aggressive and cause severe health effects that prevent you from working and earning an income.
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