Researchers Make Groundbreaking Progress in Reducing Transplanted Organ Rejection
Researchers at the University of Pittsburgh School of Medicine may have found a new way of preventing organ rejection in transplant patients. Organ rejection can cause a patient to require multiple transplants and decreases the viability of the small pool of donor organs available to patients in need.
The findings of the study, published in Nature Communications, show that dendritic cells are the key components in causing organ rejection. These cells are the triggers responsible for bringing the donor’s antigens to the recipient’s T cells, which causes an immune response in the recipient’s body and ultimately rejection.
With this knowledge, the international team of researchers is seeking to develop new methods of targeting the dendritic cells within the transplanted organs. This would prevent them from activating T cells already inside the transplanted organ.
One trial of inhibiting dendritic cells involved elimination of the transplant-infiltrating cells. This inhibition resulted in a decrease of T cells and a longer survival of the transplanted organ.
Organ Failure and Transplants Can Lead to Disability
Patients waiting for transplant matches are often unable to work due to illness or treatment side effects. In addition, with current transplant rejection prevention, transplant recipients must take immunosuppressants which can increase the risk of infections and disease.
If you are unable to work due to organ failure or transplant complications, the Disability Help Group will help you explore your options for recovering disability benefit.
Contact us today at 800-800-2009 to schedule a consultation with one of our disability advocates.