Targeting Newly Discovered Protein Could Reverse Insulin Resistance

Posted on November 7, 2016 by Disability Help Group

Insulin resistance, when the body fails to respond properly to insulin, is a common precursor to the development of prediabetes or type 2 diabetes. While there are some medications on the market to reduce the impact of insulin resistance, researchers at the University of California-San Diego might have discovered a way to actually reverse the resistance.

The researchers began their study, published in the journal Cell, by looking at how chronic inflammation relates to insulin resistance. While analyzing the fat cells of the tissues of obese subjects, the team found high levels of macrophages. Macrophages are a type of immune cell that can cause chronic inflammation and insulin resistance in obese patients.

While observing the behaviors of macrophages, the researchers noticed high levels of the Gal3 protein in patients with high macrophage levels. The more Gal3 present in the tissue samples, the more macrophages were present. The researchers also found that the protein causes insulin resistance even when inflammation is not present.

Researchers found that by blocking Gal3 in diabetic mice cells, they improved “insulin sensitivity” and could potentially reverse insulin resistance.

Untreated Diabetes Leads to Many Severely Disabling Conditions

Well-managed diabetes is not typically a case for Social Security disability benefits. However, unmanaged diabetes can lead to circulatory issues, heart disease, and nervous system damage.

When these conditions become severe, they can impair your ability to work and earn a substantial income to support your family.

If you or a loved one suffers from disabling diabetes complications, the Disability Help Group is here to help. Call us at 800-800-2009 to schedule a free consultation with our disability advocates today.