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Stanford Scientists Develop Cell Receptor to Grab and Remove Cancer-Causing Molecules

Posted on December 2, 2016 by Disability Help Group

The Gas6 molecule is a key cancer-causing element in the progression of pancreatic and ovarian cancer. When medical care leaves this molecule alone, it allows these cancers to grow and develop into later-stage disease. Scientists believe stopping these cancer-causing molecules is a key to halting the disease’s progression.

Researchers at the Stanford University School of Medicine developed a new receptor designed to catch and trap the Gas6 molecule. When used in conjunction with chemotherapy, the receptor attracts and captures the Gas6 molecules using its unique half-circle shape.

The researchers are calling it a “decoy receptor” as it tricks the Gas6 molecules into binding with it, thinking it is their normal receptor, Axl. Instead, the decoy prevents that bond and creates a previously unknown phenomenon.

When Gas6 does not bind to Axl, the pancreatic or ovarian cancer cells release molecules that damage cancer’s DNA, causing cancer cell death.

When the researchers gave the decoy to mice, they found the decoy removed the molecules and stopped them from activating their normal receptor. This effectively stopped the cells and disease from growing.

The researchers found that the decoy is about 350 times more effective at binding to Gas6 than Axl is.

With these findings, which the researchers will publish in The Journal of Clinical Investigation, researchers are hoping to develop a new protocol for treatment of pancreatic and ovarian cancer.

Contact the Disability Help Group for Assistance with Your Disability Benefits Claim

Cancers of all types can qualify you for Social Security disability benefits if their symptoms or treatment keep you from working.

The Disability Help Group is here to assist you with filing your benefits claim or appealing a denied claim. Call 800-800-2009 to learn about your rights to benefits and how our disability advocates can help you settle your claim.