Research Could Lead to Urine Test to Help Identify Alzheimer’s Disease
Developing a definitive test for Alzheimer’s disease is one of the many goals researchers have to help improve the early detection and prevention of this disease. A recent project regarding Alzheimer’s disease detection brought together experts from several agencies, including the Monell Chemical Sense Center and the U.S. Department of Agriculture. The team studied mice with Alzheimer’s disease and assessed their urine odor signatures. Researchers bred three different types of mice for the purpose of the study, each with a different human gene sequence represented in their bodies and activated to mimic Alzheimer’s disease. Researchers achieved the mimicry by increasing the amyloid precursor protein in the brains of the mice (called APP mice) to create the amyloid plaques that clog human brains as Alzheimer’s develops. Results of the study, published in Scientific Reports, showed that each different strain of APP mice had a distinct urine odor signature. All of the mice had the same basic compounds found in their urine samples, but the APP mice had them in different concentrations from the control mice. These different concentrations created the different signatures. The difference in signatures did not vary with the mouse’s age or the progression of the disease, which ties the signature to the specific gene rather than the progression of Alzheimer’s. Using urine analysis to detect Alzheimer’s disease is a promising and non-invasive test method that could reduce the cost and time it takes to diagnose the condition. This could lead to faster treatment and more early stage interventions.
Early Detection in Alzheimer’s Can Help Improve Quality of Life
Alzheimer’s disease is a mental condition that has no known cure and few effective treatments. The earlier the mental decline is detected, the faster existing treatments can be applied. Disability Help Group provides support for families with disabled individuals. We can help with your disability claim; just contact us online or call us at 1-(800)-800-3332 to schedule a consultation with our disability advocates!