Researchers Discover Common Blood Pressure Drug Has Positive Results in Reversing Diabetes
The blood pressure medication verapamil is the focus of a new study that seeks to determine if the drug can be used as an effective method of reversing type 1 diabetes. Researchers at the University of Alabama at Birmingham have tested the drug on mice with type 1 diabetes and are now seeking to perform a human trial.
The researchers found that verapamil lowered levels of TXNIP in beta cells. TXNIP is a protein that when overproduced, kills the pancreatic beta cells that help produce insulin. TXNIP is rapidly produced when blood sugar is high.
The mice in the trials had blood sugar levels over 300 mg/dL. After administration of the verapamil, TXNIP levels were lowered and the disease was reversed.
The research team has received a $2.1 million grant from the Juvenile Diabetes Research Foundation (JDRF) to conduct a three-year human clinical trial in 2015. The team is looking for participants to take the medication in a controlled study, the first of its kind to not use immunosuppressive or immune modulatory medications which can cause harsh side effects.
If successful, this could lead to the first viable cure for type 1 diabetes, which affects approximately three million Americans according to the JDRF. More than 15,000 children and 15,000 adults are diagnosed with type 1 diabetes each year, and the disease will get progressively worse without proper diabetes management and a healthy lifestyle.
Type 1 diabetes can cause several additional disabling conditions as the disease progresses, ranging from hypertension to neuropathy and in some cases resulting in the need for limb amputation. The Offices of Disability Help Group are here to offer support to type 1 diabetics whose health complications impair them from working and earning wages. If you have been unable to work and were denied Social Security disability benefits, contact us for a free claim consultation. Call today – 1-(800)-800-3332.