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Study Could Lead to Prevention of Chemotherapy Resistance

Posted on November 2, 2016 by Disability Help Group

Chemotherapy damages cancer cells by breaking their DNA, making it impossible for the cancer cells to survive. However, some cancer cells can repair these breaks, making themselves resistant to the chemotherapy drugs. This chemotherapy resistance is a leading cause of cancer relapse and progression when patients have exhausted other treatment methods.

Researchers at the University of Sheffield in South Yorkshire, England have discovered the protein modification that helps shield and repair cancer cell DNA breaks. The researchers believe this modification is the cause of chemotherapy resistance. The modified proteins are part of a cancer cell’s “repair toolkit,” and doctors are now looking for ways to reduce the toolkit’s efficiency.

During the study, published in Nucleic Acids Research, the team noticed that the speed of the toolkit’s work to repair and shield the DNA cracks is how chemotherapy resistance occurs. If further research can develop a method to slow down the protein modifications and their actions, chemotherapy drugs could continue to be effective at treating certain types of cancer.

When Cancer Patients Run Out of Treatment Options, They Might Qualify for Social Security Disability Benefits

Cancers of all types are difficult to claim as disabling conditions because early stage cancer may not be severe enough to prevent you from working. To claim cancer for Social Security disability benefits, you must prove that the cancer is failing to respond to treatments and has relapsed or metastasized.

If you are having trouble applying for disability benefits, the Disability Help Group urges you to give us a call at 800-800-2009 to schedule a free consultation with our disability advocates.