Testosterone Therapy Could Benefit Men with Low-T and Type 2 Diabetes
Studies conducted in the early 2000’s found a link between low testosterone levels in men and decreased insulin sensitivity, often resulting in development of type 2 diabetes. Further investigation into the extended symptoms of low testosterone found that obese men and teenage boys were also more prone to having low testosterone levels.
Using this information, researchers from the Jacobs School of Medicine and Biomedical Sciences at the University of Buffalo, NY conducted a study to determine if there was a correlation between low testosterone and type 2 diabetes. Ninety-four men with type 2 diabetes participated in the study, 44 of whom had low testosterone.
The men with low testosterone expressed lower levels of insulin-signaling genes and lower insulin sensitivity than the men with normal testosterone levels. The low testosterone participants randomly received testosterone supplements by injection or a placebo over the course of 24 weeks. Those who received the testosterone supplement developed better insulin sensitivity and expressed more insulin signaling genes.
While the low testosterone participants who received testosterone supplements saw a decrease of 12 milligrams per deciliter in their fasting glucose levels, there was no significant reduction in the hemoglobin A1C (HbA1c) levels. The HbA1c is a strong indicator of diabetic control and improvement, and the researchers believe that improvements could be seen over the course of a longer study.
This study has opened up new theories of testosterone being a metabolic hormone and potential for other avenues of investigation. The research team is now looking to perform future studies relating testosterone to insulin resistance and inflammation control.
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